A study has been conducted by the Tata Institute of Fundamental Research (TIFR), Colaba which has brought into the light that glucose is not always good for a person’s health and can also act as a harmful agent in causing lifestyle disorders as well as diseases that come with age.
This research was conducted in Pune, Maharashtra in the branch of Indian Institute of Science Education and Research. The findings indicate that glucose has the ability to bind itself into a different kind of gene called longevity gene. It is named Sirtuin 1 (SIRT1) which is found in the liver and is responsible for the modifications in the gene’s functions. When this occurs in the appropriate amount, it balances the blood sugar levels but on the other hand, if this occurs excessively, it is most likely to lead to metabolic diseases.
The conclusion that scientists gave over this issue was that by the SIRT 1 modification of glucose can cause diabetes and hyper inflammation, but there is excess modification, the glucose causes the body to age and can even lead to obesity. SIRT 1 was always thought to be helpful in the mitigation of diseases such as diabetes, neurodegeration, cardiovascular dysfunctions and even cancer and aging.
Metabolic diseases are generally caused due to the kind of feeding habits one has and the imbalanced diet that is being followed. Another aspect that adds to the significance of the study is that the body’s metabolic balance is majorly managed by the liver as it is responsible for the production of fat, breakdown of sugar and other such functions. This brings in the conclusion that the liver has to respond properly and healthily to any kind of feeding cycles and the fasts that come in the way once in a while. If this does not occur, the metabolism becomes imbalanced.
“The study has shown that while there are efforts to find therapeutic activators for SIRT1, both over-activation and under-activation of this longevity factor could lead to diseases,” said Ullas Kolthur, lead investigator and professor at the department of biological sciences, TIFR. The study was published earlier this week in the Proceedings of National Academy of Sciences of the United States of America, an international peer-reviewed multidisciplinary scientific journal.